Cardiovascular Research Cluster Bern

2025

Publications 2025

Ramedani S, Kelesoglu E, Stutzig N, Von Tengg-Kobligk H, Daneshvar Ghorbani K, Siebert T.Physiol. Quantification of training-induced alterations in body composition via automated machine learning analysis of MRI images in the thigh region: A pilot study in young females. Rep. 2025 Feb;13(3):e70187. doi: 10.14814/phy2.70187.

Bernhard B, Gräni C. Reply: What Is the Diagnostic and Prognostic Value of the Electrocardiographic QRS Attenuation in Myocarditis? J Am Coll Cardiol. 2025 Feb 4;85(4):e59. https://doi.org/10.1016/j.jacc.2024.11.037

Morrison M, Bucciarelli A, Korda A, Goetz LS, Caversaccio MD, Obrist D, Mantokoudis G. Impact of Vibrations and Rapid Decelerations on SemontPLUS Maneuver Efficacy: An In Vitro Study. Otol Neurotol. 2025 Jan 29; https://doi.org/10.1097/MAO.0000000000004412

Urbanek L, Heine GH, Reddavid C, Saw J, Kawamura I, Reddy VY, Galea R, Räber L, Sedaghat A, Della Rocca DG, Natale A, Fassini G, Tondo C, Doshi SK, Peng DS, von Bardeleben RS, Kreidel F, Schmidt B. Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation and Hemodialysis: An International, Multicentric Registry. JACC Clin Electrophysiol. 2025 Jan 28;11(1):71–82. https://doi.org/10.1016/j.jacep.2024.09.038

Woelders ECI, Onuma Y, Ninomiya K, O’Leary N, Damman P, Peeters DAM, Hof AWJ van ’t, Valgimigli M, Vranckx P, Windecker S, Serruys PWJC, van Geuns RJM. Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antiplatelet strategy? Open Heart. 2025 Jan 28;12(1):e003083. https://doi.org/10.1136/openhrt-2024-003083

Veen KM, Ahmed M, Stark C, Botta L, Anastasiadis K, Bernhardt A, Berchtold-Herz M, Caliskan K, Reineke D, Damman K, Fiane A, Gkouziouta A, Gollmann-Tepeköylü C, Najjar E, Hulman M, Iacovoni A, Loforte A, Merkely B, Musumeci F, Comisso M, Němec P, Netuka I, Özbaran M, Potapov E, Pya Y, Rábago G, Ramjankhan F, Scandroglio AM, Pieri M, Reichenspurner H, Dashkevich A, Stockman B, Vanderheyden M, Tops L, Wahlers T, Przybyłowski P, Zimpfer D, Løgstrup BB, Santer D, Färber G, Gummert J, Meyns B, de By TMMH, Schoenrath F. The European Registry for Patients with Mechanical Circulatory Support (EUROMACS) of the European Association for Cardio-Thoracic Surgery Fourth report: Focus on standardized outcome ratios. Eur J Cardiothorac Surg. 2025 Jan 28;ezaf016. https://doi.org/10.1093/ejcts/ezaf016

Erdoes G, Milojevic M, Rocca B, Koster A. Clinical guidelines for a dry land: challenges in developing recommendations for DOAC management in emergent cardiac surgery. Eur J Cardiothorac Surg. 2025 Jan 28;ezaf015. https://doi.org/10.1093/ejcts/ezaf015

Fischer K, Bastiaansen JAM. Expanding the volume on 4D flow CMR : Editorial for “Robustness of 4D flow MRI derived aortic wall shear stress and pulse wave velocity across different protocols in healthy controls and in patients with bicuspid aortic valve.” Int J Cardiovasc Imaging. 2025 Jan 27; https://doi.org/10.1007/s10554-025-03335-8

Braschler L, Nikolaidis PT, Thuany M, Chlíbková D, Rosemann T, Weiss K, Wilhelm M, Knechtle B. Physiology and Pathophysiology of Marathon Running: A narrative Review. Sports Med Open. 2025 Jan 27;11(1):10. https://doi.org/10.1186/s40798-025-00810-3

Karaolanis GI, Kotopoulos K, Jungi S, Kotelis D, Makaloski V. Fenestrated Anaconda Endograft for the Treatment of Complex Aortic Aneurysms: Systematic Review and Meta-Analysis. J Endovasc Ther. 2025 Jan 24;15266028251313947. https://doi.org/10.1177/15266028251313947

Milzi A, Rodriguez AE, Piccolo R, Bonaa KH, Varenne O, Landi A, Kaiser C, Remkes W, Räber L, de la Torre Hernandez JM, Valgimigli M. Do drug-eluting stents increase non-cardiac mortality? Can J Cardiol. 2025 Jan 23;S0828-282X(25)00071-6. https://doi.org/10.1016/j.cjca.2024.12.038

Amacher SA, Zimmermann T, Gebert P, Grzonka P, Berger S, Lohri M, Tröster V, Arslani K, Merdji H, Gebhard C, Hunziker S, Sutter R, Siegemund M, Gebhard CE, Swiss ICU Trial Group. Sex disparities in ICU care and outcomes after cardiac arrest: a Swiss nationwide analysis. Crit Care. 2025 Jan 23;29(1):42. https://doi.org/10.1186/s13054-025-05262-5

Mader A, Haeberli D, Larcher B, Dopheide JF, Saely CH, Heinzle CF, Amann P, Schindewolf M, Festa A, Drexel H. Contribution of type 2 diabetes to major adverse cardiovascular events (MACE) in a long-term observational study with different stages of atherosclerosis. Sci Rep. 2025 Jan 22;15(1):2792. https://doi.org/10.1038/s41598-024-84985-x

Fortmeier V, Lachmann M, Stolz L, von Stein J, Rommel KP, Kassar M, Gerçek M, Schöber AR, Stocker TJ, Omran H, Fett M, Tervooren J, Körber MI, Hesse A, Harmsen G, Friedrichs KP, Yuasa S, Rudolph TK, Joner M, Pfister R, Baldus S, Laugwitz KL, Windecker S, Praz F, Lurz P, Hausleiter J, Rudolph V. Simplified Outcome Prediction in Patients Undergoing Transcatheter Tricuspid Valve Intervention by Survival Tree-Based Modelling. JACC Adv. 2025 Jan 22;4(2):101575. https://doi.org/10.1016/j.jacadv.2024.101575

Cannata A, Segev A, Madaudo C, Bobbio E, Baggio C, Schütze J, Gentile P, Sanguineti M, Monzo L, Schettino M, Ferone E, Elshanoury A, Younis A, Palazzini M, Ferroni A, Giani V, Sadler M, Di Lisi D, Albarjas M, Calò L, Sado D, Polte CL, Garascia A, Scott PA, Shah AM, Giacca M, Sinagra G, Bollano E, McDonagh T, Tschöpe C, Novo G, Ammirati E, Beigel R, Gräni C, Merlo M, Ameri P, Bromage DI. Elevated Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Acute Myocarditis. JACC Heart Fail. 2025 Jan 22;S2213-1779(24)00865-5. https://doi.org/10.1016/j.jchf.2024.11.003

Yildiz M, Schoenhoff F, Werdecker V, Nucera M, Mosbahi S, Zhao Y, Goel N, Berezowski M, Lawrence K, Kapoor S, Kreibich M, Berger T, Kletzer J, Bavaria J, Szeto W, Siepe M, Czerny M, Desai N. Revisiting ascending aortic resection in the elective valve-sparing root replacement: assessing the benefits and necessity of hemiarch replacement at three centres. Eur J Cardiothorac Surg. 2025 Jan 20;ezaf006. https://doi.org/10.1093/ejcts/ezaf006

Windecker S, Tomii D. Myval transcatheter heart valve system: a new TAVI contender and remaining uncertainties. EuroIntervention. 2025 Jan 20;21(2):e97–9. https://doi.org/10.4244/EIJ-E-24-00067

Ekundayo B, Arullampalam P, Gerber CE, Hämmerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D. Identification of a binding site for small molecule inhibitors targeting human TRPM4. Nat Commun. 2025 Jan 19;16(1):833. https://doi.org/10.1038/s41467-025-56131-2

Scherr D, Turagam MK, Maury P, Blaauw Y, van der Voort P, Neuzil P, Reichlin T, Metzner A, Vijgen J, Kautzner J, Boveda S, Anic A, Hansen J, Manninger M, Sommer P, Anselme F, Willems S, Deneke T, Tilz R, Steven D, Wakili R, Jais P, Funasako M, Arentz T, Rollin A, Mulder BA, Ouss A, Petru J, Kueffer T, Lemoine MD, Koopman P, Peichl P, Adelino R, Jurisic Z, Ruwald M, Eberl AS, Sohns C, Savoure A, Nentwich K, Gunawardene M, Heeger CH, Sultan A, Bohnen JE, Kupusovic J, Derval N, Lehrmann H, Ekanem E, Reddy VY. Repeat Procedures After Pulsed Field Ablation for Atrial Fibrillation: MANIFEST-REDO Study. Europace. 2025 Jan 17;euaf012. https://doi.org/10.1093/europace/euaf012

Witthöft A, Marcin T, Thuany M, Scheer V, Nikolaidis PT, Wilhelm M, Weiss K, Rosemann T, Knechtle B. Running trends in Switzerland from 1999 to 2019: An exploratory observational study. PLoS One. 2025 Jan 16;20(1):e0311268. https://doi.org/10.1371/journal.pone.0311268

Haider A, Bengs S, Portmann A, Fröhlich S, Etter D, Maredziak M, Warnock GI, Akhmedov A, Kozerke S, Keller C, Montecucco F, Weber B, Mu L, Buechel RR, Regitz-Zagrosek V, Kaufmann PA, Camici GG, Ametamey SM, Gebhard C. Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury. Biol Sex Differ. 2025 Jan 16;16(1):2. https://doi.org/10.1186/s13293-024-00673-5

Agnelli G, Hoffmann U, Hainaut P, Gaine S, Ay C, Coppens M, Schindewolf M, Jimenez D, Fronk EM, Souza J, Laeis P, Bramlage P, Brüggenjürgen B, Levy P, Cohen AT, ETNA-VTE-Europe investigators. Treatment of Venous Thromboembolism with Edoxaban over 18 Months: Results from ETNA-VTE Europe. Thromb Haemost. 2025 Jan 16; https://doi.org/10.1055/a-2497-4089

Waschke J, Amagai M, Becker C, Delmar M, Duru F, Garrod DR, Gerull B, Green KJ, Hertl M, Kowalczyk AP, Niessen CM, Nusrat A, Schinner C, Schlegel N, Sivasankar S, Vielmuth F, Spindler V. Meeting report - Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases. J Cell Sci. 2025 Jan 15;138(2):JCS263796. https://doi.org/10.1242/jcs.263796

Boudon A, Locatelli I, Gencer B, Carballo D, Klingenberg R, Räber L, Windecker S, Rodondi N, Lüscher T, Matter CM, Mach F, Muller O, Nanchen D. Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland. BMJ Open. 2025 Jan 15;15(1):e088262. https://doi.org/10.1136/bmjopen-2024-088262

Haberman D, Estévez-Loureiro R, Czarnecki A, Melillo F, Adamo M, Villablanca P, Sudarsky D, Praz F, Perl L, Freixa X, Scotti A, Fefer P, Spargias K, Fam N, Manevich L, Masiero G, Nombela-Franco L, Pascual I, Crimi G, Ninios V, Beeri R, Benito-Gonzalez T, Arzamendi D, Fernández-Peregrina E, Giannini F, Mangieri A, Poles L, George J, Echarte Morales JC, Caneiro-Queija B, Denti P, Schiavi D, Latib A, Chrissoheris M, Danenberg H, Tarantini G, Dvir D, Maisano F, Taramasso M, Shuvy M. Transcatheter edge-to-edge repair in severe mitral regurgitation following acute myocardial infarction - aetiology-based analysis. Eur J Heart Fail. 2025 Jan 14; https://doi.org/10.1002/ejhf.3582

Tarantini G, Tang GHL, Pilgrim T, Kim WK, Greenbaum A, Castriota F, Webb JG, Nombela Franco L, De Backer O, Hartikainen T, Codner P, Koren O, Patel V, Meier D, Tomii D, Ueyama HA, Paredes-Vázquez JG, Arturi F, Kornowski R, Makkar RR, Cardaioli F, Nai Fovino L, THIRD Registry Investigators. Clinical Characteristics and Outcomes of Patients Undergoing 3 Aortic Valve Interventions: The THIRD Multicenter Registry. JACC Cardiovasc Interv. 2025 Jan 13;18(1):103–15. https://doi.org/10.1016/j.jcin.2024.10.037

Filipovic MG, Guensch DP. Pro: Remimazolam: New Impetus for the Anesthesia of Critically Ill and High-risk Cardiovascular Patients. J Cardiothorac Vasc Anesth. 2025 Jan 13;S1053-0770(25)00039-4. https://doi.org/10.1053/j.jvca.2025.01.010

Alaour B, Tomii D, Nakase M, Heg D, Stortecky S, Lanz J, Samim D, Reineke D, Praz F, Windecker S, Pilgrim T. Hemodynamic Valve Deterioration After Transcatheter Aortic Valve Replacement: Incidence, Predictors, and Clinical Outcomes. JACC Cardiovasc Interv. 2025 Jan 13;18(1):72–85. https://doi.org/10.1016/j.jcin.2024.09.039

Kassar M, Ovsenik A, Madhkour R, Corpataux N, Papadis A, Siontis G, Hunziker L, Windecker S, Praz F, Brugger N. Hyperacute Effects of Mitral Transcatheter Edge-to-Edge Repair on Left Ventricular Volumes and Functions. Am J Cardiol. 2025 Jan 10;241:9-16. https://doi.org/10.1016/j.amjcard.2024.12.038

Papazoglou DD, Béguin M, Ricchiuto M, Weiss S, Jungi S, Bosiers M, Kotelis D, Makaloski V. Thromboembolic Complications After Treatment with the INCRAFT AAA Ultra-Low-Profile Stent Graft System. J Vasc Surg. 2025 Jan 10:S0741-5214(25)00023-0. https://doi.org/10.1016/j.jvs.2025.01.004

Chong-Nguyen C, Yilmaz B, Coles B, Sokol H, MacPherson A, Siepe M, Reineke D, Mosbahi S, Tomii D, Nakase M, Atighetchi S, Ferro C, Wingert C, Gräni C, Pilgrim T, Windecker S, Blasco H, Dupuy C, Emond P, Banz Y, Losmanovà T, Döring Y, Siontis GCM. A scoping review evaluating the current state of gut microbiota and its metabolites in valvular heart disease physiopathology. Eur J Clin Invest. 2025 Jan 10:e14381. https://doi.org/10.1111/eci.14381

Randall Harrell C, Djonov V, Volarevic A, Arsenijevic A, Volarevic V. Mesenchymal Stem Cell-Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease. J Ophthalmol. 2025 Jan 10;2025:5552374. https://doi.org/10.1155/joph/5552374

Schäfer A, Alasnag M, Giacoppo D, Collet C, Rudolph TK, Roguin A, Buszman PP, Colleran R, Stefanini G, Lefevre T, Mieghem NV, Cayla G, Naber C, Baumbach A, Witkowski A, Burzotta F, Capodanno D, Dudek D, Al-Lamee R, Banning A, MacCarthy P, Gottardi R, Schoenhoff FS, Czerny M, Thielmann M, Werner N, Tarantini G. High-risk percutaneous coronary intervention in patients with reduced left ventricular ejection fraction deemed not suitable for surgical revascularisation. A clinical consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) in collaboration with the ESC Working Group on Cardiovascular Surgery. EuroIntervention. 2025 Jan 6;21(1):22-34. https://doi.org/10.4244/eij-d-23-01100

Mankerious N, Toelg R, Abdelghani M, Garcia-Garcia HM, Farhan S, Allali A, Windecker S, Lefèvre T, Saito S, Kandzari DE, Waksman R, Richardt G, Hemetsberger R. Impact of coronary artery tortuosity on outcomes following stenting with newer-generation drug-eluting stents. An analysis of the randomized BIOFLOW trials. Rev Esp Cardiol (Engl Ed). 2025 Jan 4:S1885-5857(24)00370-0. https://doi.org/10.1016/j.rec.2024.12.009

Aebersold H, Foster-Witassek F, Amberg S, Serra-Burriel M, Moschovitis G, Zannoni R, Aeschbacher S, Conte G, Beer JH, Blozik E, Bonati LH, Conen D, Felder S, Haller ML, Krisai P, Kühne M, Paladini RE, Reichlin T, Rodondi N, Sticherling C, Szucs T, Tomonaga Y, Osswald S, Schwenkglenks M, Swiss-AF Investigators. Impact of atrial fibrillation on productivity in working-age patients: an analysis of Swiss-AF prospective cohort study data. Swiss Med Wkly. 2025 Jan 2;155:3669. https://doi.org/10.57187/s.3669

Illi J, Stark AW, Ilic M, Soares Loureiro D, Obrist D, Shiri I, Räber L, Haeberlin A, Gräni C. Hemodynamic Relevance Evaluation of Coronary Artery Anomaly During Stress Using FFR/IVUS in an Artificial Twin. JACC Case Rep. 2025 Jan 1;30(1):102729. https://doi.org/10.1016/j.jaccas.2024.102729

Karaolanis GI, Geppert C, Kotopoulos K, Kotelis D, Makaloski V. Custom-made fenestrated Anaconda™ leg extension internal iliac artery aneurysm: A case report. Int J Surg Case Rep. 2025 Jan 1;127:110790. https://doi.org/10.1016/j.ijscr.2024.110790

Pitts L, Gasser S, Uzdenov M, Gaisendrees C, Bartkevics M, Kreibich M, Luehr M, Kempfert J, Schoenhoff F, Falk V, Dumfarth J. Predictors and outcomes in patients undergoing surgery for acute type A aortic dissection requiring concomitant veno-arterial extracorporeal membrane oxygenation support-a retrospective multicenter cohort study. Eur J Cardiothorac Surg. 2024 Dec 30:ezae467. https://doi.org/10.1093/ejcts/ezae467

Kletzer J, Fagu A, Eschenhagen M, Micek L, Siepe M, Czerny M, Kreibich M, Berger T. Safety and efficiency of trainees performing bilateral internal thoracic artery coronary bypass grafting using the T-graft technique. Eur J Cardiothorac Surg. 2024 Dec 26;67(1):ezae419. https://doi.org/10.1093/ejcts/ezae419