Cardiovascular Research Cluster Bern

Research groups

Ischemia / Reperfusion

Publications

Some selected publications

  • Matthias Längin, Tanja Mayr, Bruno Reichart, Sebastian Michel, Stefan Buchholz, Sonja Guethoff, Alexey Dashkevich, Andrea Baehr, Stefanie Egerer, Andreas Bauer, Maks Mihalj, Alessandro Panelli, Lara Issi, Jiawei Ying, Ann Kathrin Fresch, Ines Buttgereit, Maren Mokelke, Julia Radan, Fabian Werner, Isabelle Lutzmann, Stig Steen, Trygve Sjöberg, Audrius Paskevicius, Liao Qiuming, Riccardo Sfriso, Robert Rieben, Maik Dahlhoff, Barbara Kessler, Elisabeth Kemter, Katharina Klett, Rabea Hinkel, Christian Kupatt, Almuth Falkenau, Simone Reu, Reinhard Ellgass, Rudolf Herzog, Uli Binder, Günter Wich, Arne Skerra, David Ayares, Alexander Kind, Uwe Schönmann, Franz-Josef Kaup, Christian Hagl, Eckhard Wolf, Nikolai Klymiuk, Paolo Brenner & Jan-Michael Abicht. Consistent success in life-supporting porcine cardiac xenotransplantation. Nature 2019, 564, 430–433. DOI 10.1038/s41586-018-0765-z

  • Abdelhafez MM, Shaw J, Wilbs J, Despont A, Rieben R. Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures. J Vis Exp 2018, (133), e56856. DOI 10.3791/56856.
  • Abicht JM, Sfriso R, Reichart B, Längin M, Gahle K, Puga Yung GL, Seebach JD, Rieben R, Ayares D, Wolf E, Klymiuk N, Baehr A, Kind A, Mayr T, Bauer A. Multiple genetically modified GTKO/hCD46/HLA-E/hβ2-mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood. Xenotransplantation. 2018, e12390. DOI 10.1111/xen.12390.
  • Gygax E, Kaeser HU, Stalder M, Gahl B, Rieben R, Carrel T, Erdoes G. Type II Minimal-Invasive Extracorporeal Circuit for Aortic Valve Replacement: A Randomized Controlled Trial. Artificial Organs 2018, 00(00):00–00. DOI 10.1111/aor.13093.
  •  Zhang S, Shaw J, Banz Y, Bongoni AK, Taddeo A, Spirig R, Nolte MW, Cowan PJ, Rieben R. Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia/reperfusion injury model. J Vasc Surg 2017, S0741-5214(17)32653-8. DOI 10.1016/j.jvs.2017.10.072.
  • Puga Yung G, Bongoni A, Pradier A, Madelon N, Papaserafeim M, Sfriso R, Ayares D, Wolf E, Klymiuk N, Bähr A, Constantinescu M, Vögelin E, Kiermeir D, Jenni HJ, Rieben R, Seebach JD. Release of pig leukocytes and reduced human NK cell recruitment during ex vivo perfusion of HLA-E/human CD46 double-transgenic pig limbs with human blood. Xenotransplantation 2017, e12357. DOI 10.1111/xen.12357.
  • Sfriso R, Bongoni A, Banz Y, Klymiuk N, Wolf E, Rieben R. Assessment of the anticoagulant and anti-inflammatory properties of endothelial cells using 3D cell culture and non-anticoagulated whole blood. J Vis Exp 2017, 127:e56227. DOI 10.3791/56227.
  • Olariu R, Denoyelle J, Leclère FM, Dzhonova DV, Gajanayake T, Banz Y, Hayoz M, Constantinescu M, Rieben R, Vögelin E, Taddeo A. Intra-graft injection of tacrolimus promotes survival of vascularized composite allotransplantation. J Surg Res 2017, 218:49-57. DOI 10.1016/j.jss.2017.05.
  • Duisit J, Maistriaux L, Taddeo A, Orlando G, Joris V, Coche E, Behets C, Lerut J, Dessy C, Cossu G, Vögelin E, Rieben R, Gianello P, Lengelé B. Bioengineering a human face graft. The matrix of identity. Ann Surg 2017, 266(5):754-764. DOI 10.1097/SLA.0000000000002396.
  • Bongoni AK, Salvaris E, Nordling S, Klymiuk N, Wolf E, Ayares DL, Rieben R, Magnusson PU, Cowan PJ. Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood. Scientific Reports 2017, 7:4450. DOI 10.1038/s41598-017-04898-w. 6.
  •  Abdelhafez MM, Shaw J, Sutter D, Schnider J, Banz Y, Jenni HJ, Voegelin E, Constantinescu MA, Rieben R. Effect of C1-INH on ischemia/­reperfusion injury in a porcine limb ex vivo perfusion model. Molecular Immunology 2017, 88:11-6124. DOI 10.1016/j.molimm.2017.06.021.
  • Pischke SE, Gustavsen A, Orrem HL, Egge KH, Courivaud F, Fontenelle H, Despont A, Bongoni AK, Rieben R, Tønnessen TI, Nunn MA, Scott H, Skulstad H, Barrat-Due A, Mollnes TE. Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function. Basic Research in Cardiology 2017, 112(3):20.
  • Zhang S, Wotzkow C, Bongoni AK, Shaw-Boden J, Siegrist M, Taddeo A, Blank F, Hofstetter W, Rieben R *. Role of the plasma cascade systems in ischemia/reperfusion injury of bone. Bone 2017, 97:278-286. *co-corresponding authors
  • Kamat P, Vandenberghe S, Christen S, Bongoni AK, Meier B, Rieben R, Khattab A. Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs. PLoS ONE 2016, 11(12): e0168541.
  • Bongoni AK, Klymiuk N, Wolf E, Ayares D, Rieben R, Cowan PJ. Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation. Transplantation 2016, 100(9):1871-9.
  • Cowan P, Rieben R. Modifying the Glycome in Pigs for Xenotransplantation. Transplantation 2016, 100(3):485-486.  
  • Zhang S, Duehrkop C, Plock J, Rieben R. Inhalation anesthesia of rats: Influence of the fraction of inspired oxygen on limb ischemia/reperfusion injury. Laboratory Animals 2015, 50(3):185-197.
  • Bongoni AK, Kiermeir D, Schnider J, Jenni HJ, Garimella PS, Bähr A, Klymiuk N, Wolf E, Ayares D, Voegelin E, Constantinescu MA, Seebach JD, Rieben R. Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions. Transplantation 2015, 99(10):2061-2069.
  • Ahrens HE, Petersen B, Herrmann D, Lucas-Hahn A, Hassel P, Ziegler M,
Kues WA, Baulain U, Baars W,
Schwinzer R, Denner J, Rataj D, Werwitzke S, Tiede A, Bongoni AK, Garimella PS, Despont A,
 Rieben R, Niemann H. siRNA Mediated Knockdown of Tissue Factor Expression in Pigs for Xenotransplantation. Am J Transplant 2015, 15(5):1407-1414.
  • Bongoni AK, Kiermeir D, Denoyelle J, Jenni HJ, Burlak C, Seebach JD, Vögelin E, Constantinescu MA, Rieben R. Porcine Extrahepatic Vascular Endothelial Asialoglycoprotein Receptor 1 Mediates Xenogeneic Platelet Phagocytosis In Vitro and in Human-to-Pig Ex Vivo Xenoperfusion. Transplantation 2015, 99(4):693-701.
  • Gajanayake T, Olariu R, Leclère FM, Dhayani A, Yang Z, Bongoni AK, Banz Y, Constantinescu MA, Karp JM*, Vemula PK*, Rieben R*, Vögelin E. A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft. Sci Transl Med 2014, 6(249):249ra110.  *co-corresponding authors
  • Bongoni AK, Kiermeir D, Jenni H, Bähr A, Ayares D, Klymiuk N, Wolf E, Voegelin E, Constantinescu MA, Seebach JD, Rieben R. Complement dependent early immunological responses during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood. Xenotransplantation 2014, 21(3):230-243.
  • Bongoni AK, Kiermeir D, Jenni H, Wünsch A, Bähr A, Ayares D, Seebach JD, Wolf E, Klymiuk N, Constantinescu MA, Vögelin E, Rieben R. Activation of the Lectin Pathway of Complement in Pig-to-Human Xenotransplantation Models. Transplantation 2013, 96(9):791-799.
  • Khattab AA, Stieger S, Kamat PJ, Vandenberghe S, Bongoni A, Stone GW, Seiler C, Meier B, Hess OM, Rieben R. Effect of pressure-controlled intermittent coronary sinus occlusion (PICSO) on myocardial ischaemia and reperfusion in a closed-chest porcine model. Euro Intervention 2013, 9:398–406.
  • Duehrkop C, Banz Y, Spirig R, Miescher S, Nolte MW, Spycher M, Smith RAG, Sacks SH, Rieben R. C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage. PLoS ONE 2013, 8(8):e72059.
  • Spirig R, Schaub A, Kropf A, Miescher S, Spycher MO, Rieben R. Reconstituted high-density lipoprotein modulates activation of human leukocytes. PLoS One 2013, 8(8), e71235.
  • Spirig R, Djafarzadeh S, Regueira T, Shaw SG, von Garnier C, Takala J, Jakob SM, Rieben R, Lepper PM. Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions. PLoS One 2010 5(6):e0010983.
  • Gajanayake T, Sawitzki B, Matozan K, Korchagina EY, Lehmann M, Volk HD, Rieben R. Dextran sulfate facilitates anti-CD4 mAb-induced long-term rat cardiac allograft survival after prolonged cold ischemia. Am. J. Transpl. 2008 8(6):1151-1162.
  • Spirig R, van Kooten C, Obregon C, Nicod L, Daha M, Rieben R. The Complement Inhibitor Low Molecular Weight Dextran Sulfate Prevents TLR4-Induced Phenotypic and Functional Maturation of Human Dendritic Cells. J. Immunol. 2008;181(2):878-890.
  • Banz Y, Hess OM, Robson SC, Mettler D, Meier P, Haeberli A, Csizmadia E, Korchagina EY, Bovin NV, Rieben R. Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischemia/reperfusion injury. Eur Heart J 2005 26(21):2234-2243.
  • Laumonier T, Mohacsi PJ, Matozan KM, Banz Y, Haeberli A, Korchagina EY, Bovin NV, Vanhove B, Rieben R. Endothelial Cell protection by dextran sulfate: A novel strategy to prevent acute vascular rejection in xenotransplantation. Amer J Transpl 2004 4(2):181-187.
  • Laumonier T, Walpen AJ, Maurus CF, Mohacsi PJ, Matozan KM, Korchagina EY, Bovin NV, Vanhove B, Seebach JD, Rieben R. Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells. Transplantation 2003 76(5):838-843.
  • Rieben R, Roos A, Muizert Y, Tinguely C, Gerritsen AF, Daha MR. Immunoglobulin M–enriched human intravenous immunoglobulin prevents complement activation in vitro and in vivo in a rat model of acute inflammation. Blood 1999 93(3):942-951.